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Valproic Acid Monotherapy in Pregnancy and Major Congenital Malformations NEJM 362:2185-2193, Jentink,J., et al, 2010 See this aricle in Pubmed Article Abstract The use of valproic acid monotherapy in the first trimester was associated with significantly increased risks of several congenital malformations, as compared with no use of antiepileptic drugs or with use of other antiepileptic drugs.

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